Description

Leukotriene A4 Methyl Ester CAS NO 72345-92-7 is a key synthetic intermediate and reference standard in the study of leukotriene biosynthesis and inflammatory pathways. This compound is critical for pharmaceutical research and development, particularly in the creation of novel anti-inflammatory and respiratory therapeutics. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on immunology and metabolic pathway analysis.

Application

• Biochemical Research: Used as a critical intermediate in the study of the arachidonic acid cascade and leukotriene biosynthesis pathways.
• Pharmaceutical Reference Standard: Serves as a high-purity analytical standard for method development, validation, and quality control in drug discovery.
• Medicinal Chemistry: A vital building block for the synthesis of more complex leukotriene analogs and potential drug candidates targeting inflammation.
• Enzyme Inhibition Studies: Employed in assays to evaluate the activity of enzymes like leukotriene A4 hydrolase and its inhibitors.
• Academic Research: Supports fundamental research in immunology, cell signaling, and the molecular mechanisms of allergic and inflammatory diseases.
• Fine Chemical Synthesis: A precursor for the custom synthesis of specialized metabolites and labeled compounds for tracer studies.

Basic Information

Product Name	Leukotriene A4 Methyl Ester
CAS No.	72345-92-7
Molecular Formula	C21H32O4
Molecular Weight	348.48 g/mol
Synonyms	Leukotriene A4 methyl ester; LTA4 methyl ester; Methyl (5S,6S)-5,6-epoxy-7,9,11,14-eicosatetraenoate; (5S,6S)-5,6-Epoxy-7,9,11,14-eicosatetraenoic acid methyl ester; 5,6-Oxido-7,9,11,14-eicosatetraenoic acid methyl ester; LTA4-Me; Methyl 5,6-epoxyeicosatetraenoate
EINECS	Contact for details

Quality Control

Our Leukotriene A4 Methyl Ester is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Solubility	Soluble in ethanol, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.