Description

2,2,2-Trifluoro-1-[4-[2-(6-Methoxynaphthalen-2-Yl)Propyl]Piperazin-1-Y L]Ethanone is a high-purity, advanced pharmaceutical intermediate characterized by its trifluoroacetyl and piperazine-substituted naphthalene structure. This compound is critical for the synthesis of active pharmaceutical ingredients (APIs) targeting specific therapeutic pathways. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs, particularly in areas requiring sophisticated chemical building blocks.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of proprietary Active Pharmaceutical Ingredients (APIs) for clinical research and commercial production.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates with enhanced efficacy and pharmacokinetic profiles.
• Biochemical Reagent: Employed in biochemical assays and as a reference standard for analytical method development and validation in quality control laboratories.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	2,2,2-Trifluoro-1-[4-[2-(6-Methoxynaphthalen-2-Yl)Propyl]Piperazin-1-Y L]Ethanone
CAS No.	72278-80-9
Molecular Formula	C20H23F3N2O2
Molecular Weight	380.41 g/mol
Synonyms	1-[4-[2-(6-Methoxynaphthalen-2-yl)propyl]piperazin-1-yl]-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-[4-[2-(6-methoxy-2-naphthyl)propyl]-1-piperazinyl]ethanone; 2,2,2-Trifluoro-1-[4-[2-(6-methoxynaphthalen-2-yl)propyl]piperazin-1-yl]ethanone; 1-(4-(2-(6-Methoxynaphthalen-2-yl)propyl)piperazin-1-yl)-2,2,2-trifluoroethanone; Trifluoroacetyl derivative of 6-Methoxy-Naproxen Piperazine; 72278-80-9; 2,2,2-Trifluoro-1-[4-[2-(6-Methoxynaphthalen-2-Yl)Propyl]Piperazin-1-Y L]Ethanone
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-[4-[2-(6-Methoxynaphthalen-2-Yl)Propyl]Piperazin-1-Y L]Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material suitable for research use and can supply grades aligned with cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.