Description

31-Oxo 14,21-Dihydroxy-7-O,31-Cycloprotostreptovaricin I is a complex ansamycin-type macrocyclic lactam, a derivative of the protostreptovaricin family, with the CAS registry number 72258-35-6. This compound is of significant interest in advanced pharmaceutical research and development due to its intricate molecular architecture, which serves as a privileged scaffold for biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and synthesis of novel antibiotics, enzyme inhibitors, and other therapeutic agents targeting complex biological pathways.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor or building block in the research and development of novel antibiotic candidates.
• Biochemical Research: Used as a reference standard or probe in studies investigating the mechanism of action of ansamycin antibiotics and their interactions with biological targets like Hsp90.
• Medicinal Chemistry: Provides a core structure for structure-activity relationship (SAR) studies aimed at optimizing potency, selectivity, and pharmacokinetic properties.
• Academic Research: Employed in university and institutional labs for synthetic methodology development and the total synthesis of complex natural products.
• High-Purity Reference Material: Supplied as a characterized compound for analytical method development and validation in quality control laboratories.

Basic Information

Product Name	31-Oxo 14,21-Dihydroxy-7-O,31-Cycloprotostreptovaricin I
CAS No.	72258-35-6
Molecular Formula	C39H49NO12
Molecular Weight	723.81 g/mol
Synonyms	7-O,31-Cycloprotostreptovaricin I, 31-oxo-14,21-dihydroxy-; Protostreptovaricin I, 31-oxo-14,21-dihydroxy-7-O,31-cyclo-; Cycloprotostreptovaricin I; Ansamycin derivative; 72258-35-6; Protostreptovaricin I cyclic derivative
EINECS	Contact for details

Quality Control

Every batch of 31-Oxo 14,21-Dihydroxy-7-O,31-Cycloprotostreptovaricin I is produced and controlled under a strict quality management system. We employ advanced analytical techniques, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.