Description

4-(Trifluoromethoxy)Phenoxyacetyl Chloride is a high-value organofluorine building block and reactive intermediate. Its core value proposition lies in its ability to efficiently introduce the 4-(trifluoromethoxy)phenoxyacetyl moiety into target molecules, a functional group prized for its ability to modulate lipophilicity, metabolic stability, and biological activity. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it serves as a key precursor in the synthesis of advanced active ingredients.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances compound efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor for fluorine-containing mesogens used in high-performance display technologies.
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, improving their chemical resistance, thermal stability, and surface properties.
• Organic Synthesis & Research: A versatile reagent for constructing complex organic molecules in academic and industrial R&D laboratories.

Basic Information

Item	Details
Product Name	4-(Trifluoromethoxy)Phenoxyacetyl Chloride
CAS No.	72220-51-0
Molecular Formula	C9H6ClF3O3
Molecular Weight	254.59 g/mol
Synonyms	4-(Trifluoromethoxy)phenoxyacetyl chloride; 2-[4-(Trifluoromethoxy)phenoxy]acetyl chloride; α-Chloro-4-(trifluoromethoxy)phenoxyacetone (related); p-(Trifluoromethoxy)phenoxyacetyl chloride; 4-Trifluoromethoxyphenoxyacetyl chloride; 72220-51-0; Phenoxyacetyl chloride, 4-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our production of 4-(Trifluoromethoxy)Phenoxyacetyl Chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for your critical syntheses. Each lot undergoes comprehensive analysis, including HPLC for purity and NMR for structural confirmation. We provide detailed Certificates of Analysis (COA) with every shipment, documenting key parameters such as assay, identity, and impurity profiles to support your quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.