Description

-1-(Benzyloxycarbonyl)Piperazine-3-Carboxylic Acid CAS NO 72150-21-1 is a high-purity, protected piperazine derivative that serves as a critical building block in advanced organic synthesis. Its primary value lies in its role as a versatile intermediate for constructing complex molecules, particularly in the pharmaceutical sector. This compound is essential for research chemists and manufacturers developing active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals requiring a selectively protected amine and carboxylic acid functionality.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Peptide Chemistry: Used in the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics, where the Cbz (benzyloxycarbonyl) group provides orthogonal protection.
• Chemical Library Synthesis: A valuable scaffold for creating diverse compound libraries for high-throughput screening in drug discovery programs.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.
• Academic and R&D Laboratories: Employed in fundamental research exploring new synthetic methodologies and heterocyclic chemistry.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke fine chemicals for clients.

Basic Information

Product Name	-1-(Benzyloxycarbonyl)Piperazine-3-Carboxylic Acid
CAS No.	72150-21-1
Molecular Formula	C13H16N2O4
Molecular Weight	264.28 g/mol
Synonyms	1-Cbz-piperazine-3-carboxylic acid; 1-(Benzyloxycarbonyl)piperazine-3-carboxylic acid; 3-Carboxy-1-(phenylmethoxy)carbonylpiperazine; Piperazine-3-carboxylic acid, 1-[(benzyloxy)carbonyl]-; 1-N-Cbz-piperazine-3-carboxylic acid; 1-(Phenylmethoxycarbonyl)piperazine-3-carboxylic acid; Z-Pip(3-COOH)-OH; Z-Piperazine-3-COOH
EINECS	Contact for details

Quality Control

Our -1-(Benzyloxycarbonyl)Piperazine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and residual solvents. Our quality commitment supports applications requiring high standards, including cGMP development and non-GMP research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.