Description

Leukotriene C4 CAS NO 72025-60-6 is a potent cysteinyl leukotriene (CysLT) and a key mediator in inflammatory and allergic responses, including asthma and anaphylaxis. Its primary commercial value lies in its critical role as a high-purity reference standard and research biochemical for drug discovery and pharmacological studies. This product is essential for pharmaceutical R&D laboratories, academic research institutions, and diagnostic kit manufacturers focused on respiratory diseases, immunology, and inflammation pathways.

Application

• Pharmacological Research & Drug Discovery: Used as a reference standard in assays to screen and evaluate potential leukotriene receptor antagonists and biosynthesis inhibitors for treating asthma and allergies.
• Biochemical & Cell Signaling Studies: Serves as a critical tool for investigating the CysLT1 and CysLT2 receptor pathways, signal transduction, and the role of leukotrienes in inflammation.
• In Vitro Diagnostic (IVD) Development: Employed as a calibrator or quality control material in the development of immunoassays (e.g., ELISA) to measure leukotriene levels in biological samples.
• Academic & Clinical Research: Fundamental for studies exploring the mechanisms of inflammatory diseases, including chronic obstructive pulmonary disease (COPD), allergic rhinitis, and cardiovascular inflammation.
• Metabolite Identification & Analytical Method Development: Used as a known standard in LC-MS/MS and HPLC methods to identify and quantify leukotriene metabolites in complex matrices.

Basic Information

Product Name	Leukotriene C4
CAS No.	72025-60-6
Molecular Formula	C30H47N3O9S
Molecular Weight	625.8 g/mol
Synonyms	LTC4; (5S,6R)-6-[(1E,3E,5Z,8Z)-Tetradeca-1,3,5,8-tetraen-1-yl]-2-[(2S)-2-amino-2-carboxyethyl]sulfanyl-7,9,11,14-icosatetraenoic acid; 5(S)-Hydroxy-6(R)-S-glutathionyl-7,9-trans-11,14-cis-eicosatetraenoic Acid; 5-Hydroxy-6-S-glutathionyl-7,9,11,14-eicosatetraenoic Acid; S-(5-Hydroxy-7,9,11,14-icosatetraen-6-yl)glutathione; Leukotriene C
EINECS	Contact for details

Quality Control

Our Leukotriene C4 is produced and handled under strict quality protocols to ensure identity, purity, and stability for critical research applications. Each batch is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC and MS, to confirm compliance with stringent in-house specifications. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and identification data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is light-sensitive (store away from light) and should be allowed to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Aliquotting is recommended to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.