Description

12(S)-Hpete is a specialized, biologically active hydroperoxy fatty acid derivative, specifically the 12(S)-hydroperoxyeicosatetraenoic acid. This compound serves as a critical intermediate and signaling molecule in the study of eicosanoid biosynthesis and lipid peroxidation pathways. It is essential for researchers and manufacturers in the pharmaceutical and life science sectors who require high-purity biochemical tools for investigating inflammation, cell signaling, and oxidative stress mechanisms. The product is supplied under strict quality control to ensure batch-to-batch consistency for reliable experimental and developmental work.

Application

• Biochemical Research: Used as a key intermediate and standard in the study of lipoxygenase pathways and eicosanoid metabolism.
• Pharmaceutical Development: Serves as a reference compound and precursor in the research and development of novel anti-inflammatory and immunomodulatory agents.
• Cell Signaling Studies: Employed to investigate the role of lipid hydroperoxides in cellular signaling cascades, oxidative stress responses, and apoptosis.
• Enzyme Activity Assays: Acts as a specific substrate for studying the activity and kinetics of enzymes like 12-lipoxygenase and related peroxidases.
• Analytical Reference Standard: Provides a high-purity standard for analytical methods such as HPLC, LC-MS, and GC-MS in metabolomics and lipidomics research.
• Nutritional Science Research: Used in studies exploring the impact of oxidized lipids on metabolic health and disease models.

Basic Information

Item	Detail
Product Name	12(S)-Hpete
CAS No.	71774-10-2
Molecular Formula	C20H32O4
Molecular Weight	336.47 g/mol
Synonyms	12(S)-HPETE; (12S)-Hydroperoxyeicosa-5Z,8Z,10E,14Z-tetraenoic Acid; 12(S)-Hydroperoxyeicosatetraenoic Acid; 12S-HPETE; 12(S)-HETE Hydroperoxide; 12-Lipoxygenase Metabolite; 12(S)-HpODE (common misnomer, related compound); Arachidonic Acid 12(S)-Hydroperoxide
EINECS	Contact for details

Quality Control

Every batch of 12(S)-Hpete is manufactured and analyzed under stringent quality protocols to ensure the highest standards of purity and identity. Our quality commitment includes comprehensive analytical characterization using techniques such as HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming critical parameters including assay purity, enantiomeric excess, and absence of key impurities. We adhere to cGMP principles for manufacturing where applicable to support regulatory filings in pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at or below -20°C under an inert atmosphere (e.g., argon or nitrogen). The product is easily oxidized and moisture-sensitive; allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. Keep away from strong acids, bases, and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous oil or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95%
Enantiomeric Purity (Chiral HPLC)	≥ 98% 12(S) isomer
Related Substances (HPLC)	Total impurities ≤ 3.0%
Solvent Content (Residual Solvents)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.