Description

4-Keto 13-cis-Retinoic Acid Methyl Ester is a high-purity synthetic retinoid derivative, a key intermediate in the synthesis of biologically active vitamin A analogs. This compound is valued for its precise chemical structure, which is critical for research and development in advanced pharmaceutical applications. It is primarily utilized by R&D chemists and manufacturers in the pharmaceutical, biotechnology, and advanced material science sectors for developing novel therapeutic agents and studying retinoid signaling pathways.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel retinoid-based drugs targeting dermatological conditions, oncology, and metabolic disorders.
• Biochemical Research: Used as a reference standard and probe in academic and industrial research to study retinoid receptor (RAR/RXR) activity, cell differentiation, and apoptosis.
• Cosmeceutical R&D: Serves as a precursor in the development of advanced active ingredients for anti-aging and skin-renewal formulations.
• Process Chemistry: Employed in scaling up production processes for complex retinoid molecules, requiring high chemical purity and batch-to-batch consistency.
• Analytical Standard: Provides a certified reference material for quality control and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical laboratories.

Basic Information

Product Name	4-Keto 13-cis-Retinoic Acid Methyl Ester
CAS No.	71748-57-7
Molecular Formula	C21H28O3
Molecular Weight	328.45 g/mol
Synonyms	Methyl 4-oxo-13-cis-retinoate; 13-cis-4-Oxoretinoic Acid Methyl Ester; 4-Keto Isotretinoin Methyl Ester; 4-Oxo-13-cis-retinoic Acid Methyl Ester; Ro 12-7310 Methyl Ester; (2Z,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid Methyl Ester, 4-oxo-; 4-Oxoisotretinoin Methyl Ester
EINECS	Contact for details

Quality Control

Our 4-Keto 13-cis-Retinoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets stringent specifications for research and pharmaceutical use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to prevent oxidation and degradation. Keep the container in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.