Description

Dihydrogrisorixin is a bioactive macrolide derivative structurally related to grisorixin, known for its ionophoric properties and selective cation transport activity. It serves as a critical research tool in mitochondrial physiology, membrane potential studies, and mechanistic investigations of potassium and calcium homeostasis. Researchers in academic laboratories, pharmaceutical R&D centers, and contract research organizations (CROs) rely on high-purity dihydrogrisorixin for reproducible, publication-grade experimental outcomes. Dihydrogrisorixin CAS NO 71641-04-8 is supplied under stringent quality controls to ensure batch-to-batch consistency and biological fidelity.

Application

• Mitochondrial membrane potential modulation in cell-based assays
• Potassium ion transport studies across synthetic lipid bilayers
• Controlled perturbation of intracellular Ca2+ flux in electrophysiology experiments
• Reference standard for LC-MS/MS method development in natural product analytics
• Tool compound for investigating oxidative phosphorylation uncoupling mechanisms
• Supporting material in structure–activity relationship (SAR) studies of polyether ionophores
• Quality control reference for grisorixin-related impurity profiling
• Calibration standard in quantitative metabolomics workflows targeting microbial secondary metabolites

Basic Information

Product Name	Dihydrogrisorixin
CAS No.	71641-04-8
Molecular Formula	C32H52O9
Molecular Weight	588.75 g/mol
Synonyms	NSC 130321; Dihydro-grisorixin; 3′-Deoxy-3′-oxodihydrogrisorixin; (3R,4R,5R,6R,7R,8R,9R,10R,11R,12R,13R,14R,15R,16R,17R,18R)-3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18-Hexadecahydro-3,5,7,9,11,13,15,17-octamethyl-1H-cyclopenta[a]phenanthrene-1,2(3H)-dione derivative; Grisorixin dihydro derivative; 3-Oxo-3,4-dihydrogrisorixin
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for identity (IR, HPLC retention time match), assay purity (≥98.5% by HPLC), and absence of critical impurities (e.g., residual solvents, heavy metals per ICH Q3C/Q3D guidelines). Testing aligns with ACS Reagent Grade expectations for research-use-only compounds.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (nitrogen or argon) to prevent oxidation. Keep away from moisture and avoid repeated exposure to ambient air. Maintain in a cool, dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Single impurity ≤0.5%; Total impurities ≤1.5%
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Heavy Metals	≤10 ppm
Water (Karl Fischer)	≤0.5%
Specific Rotation [α]D²⁵	+42° to +48° (c = 1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.