Description

24,24-Difluoro-25-Hydroxyvitamin D3 is a fluorinated analog of the biologically active form of vitamin D, designed to enhance metabolic stability and receptor binding affinity. This compound is a critical intermediate and reference standard in pharmaceutical research, particularly for developing novel therapeutics targeting vitamin D pathways. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors focused on metabolic bone diseases, oncology, and immunology.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of advanced vitamin D analogs with improved pharmacokinetic profiles.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related pharmaceutical products.
• Biochemical Research: Employed in studies investigating the vitamin D receptor (VDR) mechanism of action, gene regulation, and cell differentiation.
• Drug Discovery & Development: Serves as a lead compound or precursor for developing new treatments for osteoporosis, psoriasis, and certain cancers.
• Metabolic Studies: Utilized in research to understand the impact of fluorination on the metabolism and biological activity of vitamin D compounds.

Basic Information

Product Name	24,24-Difluoro-25-Hydroxyvitamin D3
CAS No.	71603-41-3
Molecular Formula	C₂₇H₄₂F₂O₂
Molecular Weight	436.62 g/mol
Synonyms	1α,25-Dihydroxy-24,24-difluorovitamin D3; 24,24-Difluoro-1α,25-dihydroxycholecalciferol; 24,24-Difluoro-1α,25-dihydroxyvitamin D3; 24,24-Difluoro-1,25-dihydroxyvitamin D3; 24,24-Difluoro-1,25-(OH)₂D₃; Falecalcitriol intermediate; Ro 23-6013; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4R)-6,6-Difluoro-4-hydroxy-1-methyl-2-hexen-1-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol
EINECS	Contact for details

Quality Control

Our 24,24-Difluoro-25-Hydroxyvitamin D3 is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed HPLC purity data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at -20°C or below to prevent oxidation and ensure long-term stability. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.