Description

(5S,12S)-Dihydroxy-(6E,8E,10E,14Z)-Eicosatetraenoic Acid is a specialized dihydroxy fatty acid and a member of the lipoxin family of bioactive lipid mediators. This compound is significant for its role as a potent, endogenous pro-resolving mediator involved in the active termination of inflammation and the promotion of tissue repair. It is primarily needed by researchers and developers in the pharmaceutical and biotechnology sectors for advanced studies in immunology, inflammation resolution, and the development of novel therapeutic agents.

Application

• Biomedical Research: Critical tool for investigating the molecular mechanisms of inflammation resolution, cellular signaling pathways, and immune modulation.
• Drug Discovery & Development: Serves as a reference standard and a potential lead compound for developing new anti-inflammatory and pro-resolving therapeutics.
• In Vitro & In Vivo Studies: Used in cell culture assays and animal models to study its effects on leukocyte trafficking, cytokine production, and tissue regeneration.
• Analytical Standard: Essential high-purity standard for qualitative and quantitative analysis using techniques like HPLC, LC-MS, and ELISA in analytical and bioanalytical laboratories.
• Biochemical Pathway Analysis: Employed to study the arachidonic acid metabolic cascade and the biosynthesis of specialized pro-resolving mediators (SPMs).

Basic Information

Product Name	(5S,12S)-Dihydroxy-(6E,8E,10E,14Z)-Eicosatetraenoic Acid
CAS No.	71548-19-1
Molecular Formula	C₂₀H₃₂O₄
Molecular Weight	336.47 g/mol
Synonyms	Lipoxin A4 (LXA4); (5S,12S)-Dihydroxy-6,8,10,14-eicosatetraenoic Acid; 5(S),12(S)-DiHETE; 5S,12S-DiHETE; (5S,12S)-DiHETE; LXA4; 5(S),12(S)-Dihydroxy-6E,8E,10E,14Z-eicosatetraenoic Acid
EINECS	Contact for details

Quality Control

Our high-purity (5S,12S)-Dihydroxy-(6E,8E,10E,14Z)-Eicosatetraenoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and relevant physicochemical data.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. This product is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95% (Area %)
Assay	≥ 98%
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.