Description

(R,S)-n-Nitrosoanatabine is a nitrosated derivative of the tobacco alkaloid anatabine, identified by CAS NO 71267-22-6. This compound is of significant interest in analytical and biochemical research, particularly for studying nitrosamine formation and metabolism. It serves as a critical reference standard and intermediate for researchers in toxicology, analytical chemistry, and pharmaceutical development who require high-purity, well-characterized nitrosamine compounds.

Application

• Analytical Reference Standard: Primary use as a certified standard for the accurate quantification of nitrosamines in complex matrices via HPLC, GC-MS, or LC-MS/MS.
• Toxicological Research: Employed in studies investigating the formation, metabolic pathways, and carcinogenic potential of tobacco-specific nitrosamines (TSNAs).
• Biochemical Studies: Used as a reagent or probe to understand enzymatic interactions and DNA adduct formation related to nitrosamine exposure.
• Pharmaceutical Impurity Profiling: Serves as a critical impurity standard in the development and validation of methods for monitoring genotoxic nitrosamine impurities (GTIs) in active pharmaceutical ingredients (APIs) and drug products.
• Method Development & Validation: Essential for developing, calibrating, and validating sensitive analytical methods in compliance with regulatory guidelines (e.g., ICH M7, FDA, EMA) for nitrosamine detection.
• Food & Environmental Safety Testing: Applied in research and testing laboratories analyzing nitrosamine contamination in food products, agricultural samples, and environmental samples.

Basic Information

Product Name	(R,S)-n-Nitrosoanatabine
CAS No.	71267-22-6
Molecular Formula	C₁₀H₁₁N₃O
Molecular Weight	189.21 g/mol
Synonyms	N-Nitrosoanatabine; 1-(3-Pyridinyl)-4-(nitrosoamino)-1-butanone; N-Nitrosoanatabine (racemic); TSNA Reference Standard; Nitrosated Anatabine; Racemic n-Nitrosoanatabine; 4-(N-Nitrosoamino)-1-(3-pyridinyl)-1-butanone
EINECS	Contact for details

Quality Control

Every batch of (R,S)-n-Nitrosoanatabine is produced and controlled under strict quality management systems. We employ advanced analytical techniques including HPLC, GC-MS, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, related substances, and residual solvents is provided with each shipment, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	Yellow to light brown solid or powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.