Description

Andrographolidi Natrii Bisulfis is a water-soluble derivative of the bioactive diterpenoid lactone, andrographolide, designed to enhance bioavailability and stability. This compound is critical for ensuring consistent potency and efficacy in formulations where the parent compound's solubility and oxidative stability are limiting factors. It is primarily required by pharmaceutical, nutraceutical, and advanced research sectors for the development of injectable, oral, and topical therapeutic products.

Application

• Pharmaceutical Intermediates: As a key starting material or active pharmaceutical ingredient (API) in anti-inflammatory, hepatoprotective, and antiviral formulations.
• Injectable Solutions: For the development of parenteral drugs requiring high-purity, soluble, and stable andrographolide derivatives.
• Nutraceutical & Dietary Supplements: Used in high-end supplement blends aimed at immune support and liver health, offering improved absorption.
• Preclinical & Clinical Research: Serves as a standard or experimental compound in pharmacological and pharmacokinetic studies.
• Cosmeceuticals: Incorporated into advanced skincare products for its potential anti-inflammatory and antioxidant properties.
• Veterinary Pharmaceuticals: Applied in animal health products for similar therapeutic indications as in human medicine.

Basic Information

Product Name	Andrographolidi Natrii Bisulfis
CAS No.	71202-97-6
Molecular Formula	C20H29NaO6S
Molecular Weight	420.50 g/mol
Synonyms	Andrographolide Sodium Bisulfite; Sodium Andrographolide Bisulfite; Andrographolide Sulfonate Sodium Salt; 3-[2-[Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone Sodium Bisulfite Adduct; Andrographis Extract Derivative; Andrographolide Soluble Salt; 14-Deoxy-11,12-didehydroandrographolide Sodium Bisulfite (incorrect but common alias)
EINECS	Contact for details

Quality Control

Our Andrographolidi Natrii Bisulfis is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and purity, residual solvent analysis, and identification by IR and NMR spectroscopy. We provide Certificates of Analysis (COA) that detail compliance with in-house specifications tailored for pharmaceutical and nutraceutical applications. Customized quality standards, including alignment with ICH guidelines, can be established to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) in a desiccated environment for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Microbial Enumeration	Meets Ph. Eur. 2.6.12/2.6.13 criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.