Description

Chloromagnesium[α-(Dimethylamino)-4-(Trifluoromethyl)Benzenemethanolate] is a specialized organomagnesium reagent, commonly known as a Grignard reagent derivative, with the CAS number 71077-39-9. This compound is a critical intermediate for introducing the dimethylamino-trifluoromethylphenyl moiety into target molecules, enabling the synthesis of complex pharmaceuticals and advanced materials. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing carbon-carbon bonds and synthesizing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) containing trifluoromethyl and dimethylamino functional groups, which are prevalent in modern drug discovery.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the specific aromatic substitution pattern enhances biological activity and stability.
• Material Science Research: Serves as a precursor for creating functionalized polymers, liquid crystals, or organic electronic materials that require precise molecular architecture.
• Cross-Coupling Reactions: Acts as an efficient nucleophile in transition metal-catalyzed cross-coupling reactions (e.g., Kumada, Negishi) to form biaryl structures.
• Asymmetric Synthesis: Employed in the development of chiral ligands or catalysts, leveraging the dimethylamino group for coordination and stereochemical control.
• Fine Chemical Production: Intermediate for manufacturing dyes, pigments, and other high-value specialty chemicals with specific optical or electronic properties.

Basic Information

Product Name	Chloromagnesium[α-(Dimethylamino)-4-(Trifluoromethyl)Benzenemethanolate]
CAS No.	71077-39-9
Molecular Formula	C11H12ClF3MgNO
Molecular Weight	281.77 g/mol (approx.)
Synonyms	[4-(Dimethylamino)-α-(trifluoromethyl)benzyl]magnesium chloride; (4-(Dimethylamino)-α,α,α-trifluoro-o-tolyl)magnesium chloride; Grignard Reagent from 4-(Dimethylamino)-α,α,α-trifluoro-o-tolyl chloride; (4-(N,N-Dimethylamino)-2-(trifluoromethyl)phenyl)magnesium chloride; Magnesium, chloro[4-(dimethylamino)-α,α,α-trifluoro-o-tolyl]-; 71077-39-9; α-(Dimethylamino)-4-(trifluoromethyl)benzenemethanol chloromagnesium derivative
EINECS	Contact for details

Quality Control

Our production of Chloromagnesium[α-(Dimethylamino)-4-(Trifluoromethyl)Benzenemethanolate] adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analysis, including titration for active magnesium content and chromatographic purity assessment. Certificates of Analysis (COA) detailing assay, identity, and impurity profiles are provided to support your quality management systems and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool (15-25°C), dry, and well-ventilated area. Due to its moisture-sensitive and easily oxidized nature, the container must be kept sealed and handled under anhydrous conditions to maintain reactivity and purity.

Specification

Item	Specification
Appearance	Off-white to beige powder or solution
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 95.0% (as Grignard reagent)
Purity (HPLC)	≥ 97.0%
Solvent (if supplied as solution)	Specified (e.g., THF, Diethyl ether)
Concentration (if solution)	0.5 M - 2.0 M (customizable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.