Description

15(S)-Hpete is a specialized hydroperoxy derivative of eicosatetraenoic acid, a key intermediate in the lipoxygenase pathway of arachidonic acid metabolism. This compound is crucial for researchers investigating the biosynthesis and biological activity of eicosanoids, which are potent signaling molecules involved in inflammation and immune response. It serves as an essential biochemical tool for pharmaceutical R&D, biotechnology, and academic laboratories focused on lipidomics, enzymology, and drug discovery for inflammatory diseases.

Application

• Biochemical Research: Used as a high-purity reference standard and substrate in studies of lipoxygenase (LOX) enzyme kinetics and specificity.
• Pharmaceutical Development: Acts as a critical intermediate for synthesizing and characterizing downstream eicosanoid metabolites like leukotrienes and hepoxilins in drug discovery pipelines.
• Cell Signaling Studies: Employed to investigate the role of specific hydroperoxyeicosatetraenoic acids (HPETEs) in cellular signaling pathways related to inflammation and oxidative stress.
• Analytical Method Development: Serves as a certified standard for calibrating analytical instruments (HPLC, LC-MS) in lipidomics and metabolomics research.
• Enzyme Inhibition Assays: Utilized as a substrate for screening and evaluating potential inhibitors of 15-lipoxygenase, a target for therapeutic intervention.

Basic Information

Product Name	15(S)-Hpete
CAS No.	70981-96-3
Molecular Formula	C₂₀H₃₂O₄
Molecular Weight	336.47 g/mol
Synonyms	15(S)-HPETE; (15S)-Hydroperoxyeicosa-5Z,8Z,11Z,13E-tetraenoic Acid; 15(S)-Hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoic Acid; 15S-HPETE; 15-HPETE; 15(S)-Hpete; 15-Lipoxygenase metabolite of arachidonic acid
EINECS	Contact for details

Quality Control

Every batch of 15(S)-Hpete is produced and analyzed under strict quality protocols to ensure identity, purity, and stability for sensitive research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results from analytical methods including HPLC, NMR, and MS to confirm high chemical and isomeric purity.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent degradation due to its easily oxidized nature. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Store away from strong oxidizing or reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solution
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Isomeric Purity (15(S))	≥ 98% (by chiral analysis)
Solvent (if applicable)	Specified (e.g., Ethanol, Methanol)
Concentration (if in solution)	As specified (e.g., 1 mg/mL)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.