Description

(5E,9Z,11Z,14Z)-8-Hydroxyicosa-5,9,11,14-Tetraenoic Acid is a specialized hydroxy fatty acid derivative with a complex conjugated tetraene structure. This compound is of significant interest in biochemical research and pharmaceutical development due to its role as a potential bioactive lipid mediator and metabolic intermediate. It is primarily utilized by research institutions and life science companies engaged in the study of eicosanoid pathways, inflammation, and lipid signaling.

Application

• Biochemical Research: A key intermediate or reference standard for studying lipoxygenase and cytochrome P450 metabolic pathways of polyunsaturated fatty acids.
• Pharmaceutical R&D: Investigation into novel anti-inflammatory or pro-resolving lipid mediators derived from eicosapentaenoic acid (EPA) metabolism.
• Cell Signaling Studies: Used in vitro to explore the biological effects of specific hydroxy-eicosatetraenoic acid (HETE) isomers on cellular function.
• Analytical Reference Standard: Serves as a high-purity calibrant for LC-MS, GC-MS, and HPLC methods in lipidomics and metabolomics.
• Enzymology: Substrate for studies on the specificity and kinetics of enzymes like hydroperoxide isomerases and epoxygenases.

Basic Information

Product Name	(5E,9Z,11Z,14Z)-8-Hydroxyicosa-5,9,11,14-Tetraenoic Acid
CAS No.	70968-93-3
Molecular Formula	C₂₀H₃₂O₃
Molecular Weight	320.47 g/mol
Synonyms	8-HETE; 8-Hydroxyeicosatetraenoic Acid; 8(S)-HETE; (8S)-Hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic Acid; 8-Hydroxy-5,9,11,14-eicosatetraenoic Acid; 5,9,11,14-Eicosatetraenoic acid, 8-hydroxy-; 8-Hydroxyicosa-5,9,11,14-tetraenoic acid
EINECS	Contact for details

Quality Control

Our (5E,9Z,11Z,14Z)-8-Hydroxyicosa-5,9,11,14-Tetraenoic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical characterization including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis where applicable. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Custom synthesis and purification to meet specific project requirements are available.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Isomeric Purity	≥ 90% (5E,9Z,11Z,14Z isomer)
Solubility	Soluble in ethanol, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.