Description

1-Palmitoyl-2-Oleoyl-Sn-Glycerol-3-Phosphocholine (POPC) is a high-purity, synthetic phospholipid and a major component of biological membranes. This compound is critical for creating stable, well-defined liposomes and model membrane systems for advanced research and pharmaceutical development. It is essential for scientists and manufacturers in liposome-based drug delivery, membrane biophysics research, and diagnostic assay development.

Application

• Liposome & Lipid Nanoparticle (LNP) Formulation: A primary structural lipid for constructing drug delivery vehicles for mRNA, siRNA, and small molecule therapeutics.
• Membrane Biophysics & Biochemistry: Used to create planar bilayer membranes, vesicles, and supported lipid bilayers for studying protein-lipid interactions and membrane dynamics.
• Cell Culture & Organoid Research: Employed as a supplement to enhance membrane integrity and function in specialized cell culture media.
• Diagnostic Reagents: Serves as a key component in the development of stable, reproducible diagnostic assays and biosensors.
• Cosmetic & Dermal Formulations: Used in high-end cosmetic products for its skin-identical properties and ability to improve skin barrier function and delivery of active ingredients.
• Biomimetic Coatings: Applied in surface science to create biocompatible, non-fouling coatings for medical devices and implants.

Basic Information

Product Name	1-Palmitoyl-2-Oleoyl-sn-Glycerol-3-Phosphocholine
CAS No.	70778-75-5
Molecular Formula	C42H82NO8P
Molecular Weight	760.08 g/mol
Synonyms	POPC; 1-Palmitoyl-2-oleoylphosphatidylcholine; (16:0-18:1) PC; 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine; Phosphatidylcholine (16:0/18:1(9Z)); PC(16:0/18:1); Avanti Polar Lipids Catalog No. 850457; Lipoid PC 16:0/18:1
EINECS	274-861-5

Quality Control

Our 1-Palmitoyl-2-Oleoyl-sn-Glycerol-3-Phosphocholine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical and research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP, ISO 9001, and REACH requirements for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. For long-term stability, the product is best stored as a solid or in solution under these conditions. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or clear solution
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (Area %)
Lysophosphatidylcholine	≤ 0.5%
Solvent Residue (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%
Peroxide Value	≤ 3.0 meq/kg
Fatty Acid Composition (GC)	Conforms to 16:0 / 18:1 profile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.