Description

1-o-Octadecyl-2-o-Methyl-Sn-Glycero-3-Phosphocholine is a high-purity synthetic phospholipid, specifically an ether-linked phosphatidylcholine analogue. This compound is critical for research and development in advanced drug delivery systems, particularly for its role in forming stable, biocompatible liposomal membranes. It is primarily utilized by pharmaceutical R&D teams, formulation scientists, and manufacturers of lipid nanoparticles (LNPs) and other nanomedicines.

Application

• Lipid Nanoparticle (LNP) Formulation: A key structural lipid for constructing stable, non-viral delivery vehicles for mRNA, siRNA, and other nucleic acid therapeutics.
• Liposome Research & Development: Used as a primary or helper lipid to create liposomes with tailored membrane properties for drug encapsulation and targeted release.
• Membrane Biophysics Studies: Serves as a model membrane component in studies investigating lipid bilayer fluidity, phase behavior, and protein-lipid interactions due to its ether-linked alkyl chains.
• Diagnostic Reagent Preparation: Employed in the formulation of contrast agents or reagents for diagnostic assays requiring stable, functionalized lipid assemblies.
• Cell Culture & Transfection: Acts as a component in synthetic lipid mixtures for enhancing cell membrane fusion and improving transfection efficiency in vitro.
• Cosmetic & Dermal Formulations: Incorporated into high-end cosmetic products for its biomimetic properties, helping to restore skin barrier function and deliver active ingredients.

Basic Information

Item	Detail
Product Name	1-o-Octadecyl-2-o-Methyl-Sn-Glycero-3-Phosphocholine
CAS No.	70641-51-9
Molecular Formula	C₂₇H₅₈NO₆P
Molecular Weight	523.73 g/mol
Synonyms	D-erythro-1-O-Octadecyl-2-O-methyl-sn-glycero-3-phosphocholine; 1-O-Stearyl-2-O-methyl-sn-glycero-3-phosphocholine; 1-O-Octadecyl-2-O-methylphosphatidylcholine; Ether PC(18:0/0:0(2-O-methyl)); Methyl-D-erythro-sphingosylphosphorylcholine analogue; Sphingomyelin analogue; Synthetic ether phospholipid; O-methyl-D-erythro-sphingosylphosphorylcholine
EINECS	Contact for details

Quality Control

Our 1-o-Octadecyl-2-o-Methyl-Sn-Glycero-3-Phosphocholine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the stringent requirements for pharmaceutical and life science research. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The material is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 1.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.