Description

1,2-Dioleoylphosphatidylserine is a high-purity, synthetic phospholipid essential for advanced biomedical research and formulation development. This compound is a critical component for constructing biomimetic membranes and liposomal drug delivery systems due to its anionic headgroup and unsaturated fatty acid chains. It is primarily utilized by pharmaceutical researchers, biotech companies, and diagnostic developers working on targeted therapies, vaccine adjuvants, and cellular model systems.

Application

• Liposome & Nanoparticle Formulation: A key anionic lipid for creating stable, surface-functionalized liposomes for drug and gene delivery.
• Biomembrane & Vesicle Research: Used to construct model membranes (e.g., supported lipid bilayers, giant unilamellar vesicles) for studying membrane protein interactions, fusion events, and cellular signaling.
• Pharmaceutical Excipient: Serves as a functional excipient in advanced parenteral formulations to enhance drug encapsulation and target specificity.
• Diagnostic Reagent Component: Incorporated into assay kits and diagnostic reagents that rely on membrane-based detection or signal amplification.
• Cell Culture & Neuroscience Studies: Applied in specialized cell culture media supplements and for researching apoptotic signaling pathways where phosphatidylserine exposure is a key marker.
• Cosmetic Actives Carrier: Used in high-end cosmetic formulations as a biocompatible carrier for active ingredients to improve skin penetration and efficacy.

Basic Information

Product Name	1,2-Dioleoylphosphatidylserine
CAS No.	70614-14-1
Molecular Formula	C44H82NO10P
Molecular Weight	810.10 g/mol
Synonyms	DOPS; 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine; Phosphatidylserine (18:1); PS (18:1/18:1); (2S)-2-Amino-3-({[(2R)-2,3-bis[(9Z)-octadec-9-enoyloxy]propoxy](hydroxy)phosphoryl}oxy)propanoic acid; L-α-Phosphatidylserine, dioleoyl; OOPS
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoylphosphatidylserine is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and GMP applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines and can supply material suitable for pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. For long-term storage, desiccate to protect against moisture. Allow the sealed container to reach room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or lyophilized powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (Area %)
Solubility	Soluble in chloroform, ethanol; forms dispersions in aqueous buffer
Heavy Metals	< 10 ppm
Residual Solvents	Meets ICH limits
Peroxide Value	< 3.0 meq/kg
Water Content (KF)	< 1.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.