Description

1,3-Dioxane-4-Carboxaldehyde, 5-Hydroxy-2-Methyl-, (2R,4R,5R)- (9Ci) is a high-purity, stereochemically defined chiral building block of significant synthetic utility. This compound is valued for its unique fused dioxane-aldehyde structure, which serves as a versatile precursor in the synthesis of complex, biologically active molecules. It is primarily sought after by research and development teams in the pharmaceutical and fine chemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, antibacterial, and other therapeutic areas.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to construct complex molecular architectures with high enantiomeric purity.
• Natural Product Synthesis: Serves as a precursor in the total synthesis of natural products containing fused oxygen heterocycles.
• Agrochemical Research: Employed in the research and development of new chiral agrochemicals and plant protection agents.
• Ligand and Catalyst Development: Used as a starting material for synthesizing novel chiral ligands and organocatalysts.
• Academic and Industrial R&D: A valuable reagent for methodological development in organic chemistry and process chemistry optimization.

Basic Information

Product Name	1,3-Dioxane-4-Carboxaldehyde, 5-Hydroxy-2-Methyl-, (2R,4R,5R)- (9Ci)
CAS No.	70377-89-8
Molecular Formula	C7H12O5
Molecular Weight	176.17 g/mol
Synonyms	(2R,4R,5R)-5-Hydroxy-2-methyl-1,3-dioxane-4-carboxaldehyde; (4R)-5-Hydroxy-2-methyl-1,3-dioxane-4-carbaldehyde; 5-Hydroxy-2-methyl-1,3-dioxane-4-carboxaldehyde, (2R,4R,5R)-; D-Glycero-1,2,4-butanetriol cyclic acetal with acetaldehyde; 70377-89-8 (CAS)
EINECS	Contact for details

Quality Control

Our 1,3-Dioxane-4-Carboxaldehyde, 5-Hydroxy-2-Methyl-, (2R,4R,5R)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and stereochemical composition are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for prolonged operations to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid or clear colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (2R,4R,5R)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.