Description

(+)-Emetine Dihydrochloride Hydrate is a high-purity salt form of the alkaloid emetine, specifically the dextrorotatory enantiomer. This compound is a critical reference standard and active pharmaceutical ingredient (API) intermediate for research and development in pharmacology and parasitology. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in the study of antiprotozoal agents and cellular processes.

Application

• Pharmaceutical Reference Standard: Used for the identification, assay, and purity testing of emetine-based drug products in quality control laboratories.
• Biochemical Research: Serves as a potent and specific inhibitor of protein synthesis in eukaryotic cells, facilitating studies in molecular biology and cell physiology.
• Antiparasitic Agent Development: Acts as a key intermediate or active component in the R&D of treatments for amoebic dysentery and other parasitic infections.
• Veterinary Medicine: Employed in the formulation of antiprotozoal treatments for livestock and companion animals.
• Academic Research: Utilized in university and institutional labs for pharmacological studies and as a teaching tool for alkaloid chemistry.
• Metabolic Pathway Analysis: Applied in research to investigate the effects of protein synthesis inhibition on various cellular pathways and disease models.

Basic Information

Product Name	(+)-Emetine Dihydrochloride Hydrate
CAS No.	7083-71-8
Molecular Formula	C29H40N2O4 · 2HCl · xH2O
Molecular Weight	553.56 (anhydrous basis)
Synonyms	Emetine Hydrochloride Hydrate; (+)-Emetine 2HCl Hydrate; d-Emetine Dihydrochloride Hydrate; NSC 33669; Ipecacuanha Alkaloid; 2,3-Didehydroemetine Dihydrochloride Hydrate; Cephaeline Methyl Ether Dihydrochloride Hydrate; (2S,3R,11bS)-3-Ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]benzo[a]quinolizine-2-carboxylic acid dihydrochloride hydrate
EINECS	Contact for details

Quality Control

Our (+)-Emetine Dihydrochloride Hydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identification by spectroscopic methods, and control of specific impurities and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC, anhydrous basis)	≥98.0%
Water Content (KF)	≤8.0%
Specific Rotation [α]20/D	+15° to +25° (c=1 in H2O)
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.