Description

Emetine Dihydrochloride CAS NO 316-42-7 is a high-purity alkaloid salt derived from ipecac, primarily recognized for its potent biological activity. This compound is critical for research and development in pharmacology and biochemistry, serving as a key reference standard and active pharmaceutical ingredient (API) intermediate. It is essential for pharmaceutical manufacturers, academic research institutions, and biotechnology companies focused on antiprotozoal drug development and biochemical pathway studies.

Application

• Pharmaceutical Active Ingredient (API): Used as a key intermediate in the synthesis of antiprotozoal medications, particularly for the treatment of amoebiasis.
• Biochemical Research: Serves as a critical tool compound for studying protein synthesis inhibition, cellular apoptosis, and the mechanisms of emetine in eukaryotic cells.
• Reference Standard: Employed as a certified reference material (CRM) in analytical laboratories for quality control, method validation, and regulatory compliance testing of pharmaceutical products.
• Antiviral Research: Investigated in preclinical studies for potential activity against various RNA viruses due to its mechanism of action.
• Pharmacology Studies: Utilized in in vitro and in vivo models to understand drug metabolism, toxicity profiles, and therapeutic efficacy.
• Academic & Industrial R&D: A fundamental reagent for drug discovery programs and basic scientific research in parasitology and molecular biology.

Basic Information

Product Name	Emetine Dihydrochloride
CAS No.	316-42-7
Molecular Formula	C₂₉H₄₀N₂O₄ · 2HCl
Molecular Weight	553.56 g/mol
Synonyms	Emetine Hydrochloride; Emetine HCl; (-)-Emetine Dihydrochloride; Ipecine Dihydrochloride; NSC 33669; Cephaeline Methylether Dihydrochloride; 2,3-Didehydroemetine Dihydrochloride (related); 6',7',10,11-Tetramethoxyemetan Dihydrochloride
EINECS	206-260-5

Quality Control

Our Emetine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) that detail compliance with in-house specifications developed for research and pharmaceutical use. Our quality commitment ensures batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤5.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%
Specific Rotation	-50° to -56° (c = 1 in H₂O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.