Description

(+)-Emetine Dihydrochloride Hydrate 97 is a high-purity salt form of the ipecac alkaloid emetine, specifically the dextrorotatory enantiomer. This compound is a critical reference standard and active pharmaceutical ingredient (API) intermediate for research and development in medicinal chemistry and pharmacology. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in the study of antiprotozoal agents and the development of novel therapeutic applications.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of emetine-based products in pharmacopeial testing (e.g., USP, EP).
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key starting material or intermediate in the synthesis of prescription medications.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate its mechanism of action as a protein synthesis inhibitor.
• Antiprotozoal Agent Development: Used in R&D for novel treatments against amoebic dysentery and other parasitic infections.
• Cell Biology Studies: Applied in laboratory research to study apoptosis (programmed cell death) and cellular metabolism.
• Quality Control & Assurance: Essential for internal QC laboratories to verify the identity and purity of raw materials and finished products.

Basic Information

Product Name	(+)-Emetine Dihydrochloride Hydrate 97
CAS No.	313222-95-6
Molecular Formula	C₂₉H₄₀N₂O₄ · 2HCl · xH₂O
Molecular Weight	553.56 (anhydrous basis)
Synonyms	(+)-Emetine 2HCl Hydrate; d-Emetine Dihydrochloride Hydrate; Emetine Hydrochloride Hydrate; NSC 33669; Ipecacuanha alkaloid emetine dihydrochloride; (2S,3R,11bS)-3-Ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolyl]methyl]-2H-benzo[a]quinolizine-3-carboxylic acid dihydrochloride hydrate
EINECS	Contact for details

Quality Control

Our (+)-Emetine Dihydrochloride Hydrate 97 is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR spectroscopy, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.