Description

7-(Trifluoromethyl)-3,4-Dihydro-1H-Quinoxalin-2-One is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate this privileged scaffold into new molecular entities.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the quinoxalinone core.
• Material Science Research: Serves as a monomer or precursor for creating specialty polymers and organic electronic materials with unique properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, including novel fluorination and heterocycle formation reactions.
• Custom Synthesis & Scale-Up: Supplied for contract manufacturing and process development from gram to multi-kilogram scale.

Basic Information

Product Name	7-(Trifluoromethyl)-3,4-Dihydro-1H-Quinoxalin-2-One
CAS No.	716-81-4
Molecular Formula	C9H7F3N2O
Molecular Weight	216.16 g/mol
Synonyms	2-Oxo-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline; 7-Trifluoromethyl-3,4-dihydro-2(1H)-quinoxalinone; 1,2,3,4-Tetrahydro-7-(trifluoromethyl)-2-quinoxalinone; 7-(Trifluoromethyl)-1,2,3,4-tetrahydroquinoxalin-2-one; 7-Trifluoromethyl-1,2,3,4-tetrahydroquinoxalin-2-one; 7-Trifluoromethyl-3,4-dihydro-1H-quinoxalin-2-one; 7-Trifluoromethyl-1,2,3,4-tetrahydro-2-quinoxalinone; 7-Trifluoromethyl-2-oxo-1,2,3,4-tetrahydroquinoxaline
EINECS	Contact for details

Quality Control

Our 7-(Trifluoromethyl)-3,4-Dihydro-1H-Quinoxalin-2-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects with material suitable for research use, process development, and scale-up under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider storage under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.