Description

Phentolamine Hydrochloride CAS NO 73-05-2 is a non-selective α-adrenergic receptor antagonist. This compound is of significant commercial and research importance due to its potent pharmacological activity. It is primarily required by the pharmaceutical industry for the development and production of cardiovascular medications and diagnostic agents, as well as by research institutions for biochemical and physiological studies.

Application

• Pharmaceutical Active Ingredient (API): Key component in formulations for the treatment of hypertensive emergencies and pheochromocytoma.
• Diagnostic Agent: Used in medical diagnostics, such as the phentolamine mesylate test for complex regional pain syndrome (CRPS).
• Research Chemical: Essential tool in pharmacological and cardiovascular research for studying α-adrenergic receptor mechanisms.
• Vasodilator Formulations: Employed in topical or injectable preparations to counteract vasoconstriction caused by other drugs (e.g., norepinephrine extravasation).
• Reference Standard: Serves as a high-purity standard for analytical testing and quality control in pharmaceutical laboratories.
• Biochemical Studies: Used in in vitro assays to investigate receptor-ligand interactions and signal transduction pathways.

Basic Information

Product Name	Phentolamine Hydrochloride
CAS No.	73-05-2
Molecular Formula	C17H19N3O·HCl
Molecular Weight	317.82 g/mol
Synonyms	Phentolamine HCl; 3-[(4,5-Dihydro-1H-imidazol-2-yl)methylamino]phenol monohydrochloride; Regitine Hydrochloride; Phentolaminium Chloride; 2-(N'-p-Tolyl-N-m-hydroxyanilinomethyl)imidazoline hydrochloride; Phentolamine Chloride; Phentolamine Monohydrochloride
EINECS	200-790-9

Quality Control

Our Phentolamine Hydrochloride is manufactured under strict quality management systems. We offer material suitable for pharmaceutical research and development, with quality controls aligned with industry standards. Certificates of Analysis (COA) documenting identity, purity, and related substances are provided with each batch to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.