Description

Piperazine, 1,2,4,5-Tetramethyl-, (2R,5S)-Rel- (9Ci) is a stereochemically defined, chiral derivative of piperazine, a versatile nitrogen-containing heterocycle. This specific stereoisomer is of significant value as a sophisticated building block in the synthesis of complex molecules, particularly in the pharmaceutical sector. It is primarily sought after by research institutions and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially those targeting the central nervous system or requiring specific stereochemistry for efficacy.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce high enantioselectivity.
• Agrochemical Research: Serves as a structural component in the design of new pesticides and herbicides where the specific spatial arrangement of the tetramethyl groups is critical for biological activity.
• Material Science: Potential monomer or cross-linking agent in the synthesis of specialty polymers with tailored properties.
• Academic & Industrial R&D: Used in chemical research to explore new reaction pathways and develop novel synthetic methodologies involving constrained diamines.

Basic Information

Product Name	Piperazine, 1,2,4,5-Tetramethyl-, (2R,5S)-Rel- (9Ci)
CAS No.	697728-90-8
Molecular Formula	C8H18N2
Molecular Weight	142.24 g/mol
Synonyms	(2R,5S)-1,2,4,5-Tetramethylpiperazine; rel-(2R,5S)-1,2,4,5-Tetramethylpiperazine; (R*,S*)-1,2,4,5-Tetramethylpiperazine; 1,2,4,5-Tetramethylpiperazine, (2R,5S)-rel-; Tetramethylpiperazine (stereoisomer); Chiral Tetramethylpiperazine; TMP Derivative
EINECS	Contact for details

Quality Control

Our Piperazine, 1,2,4,5-Tetramethyl-, (2R,5S)-Rel- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and stereochemical purity suitable for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.