Description

Episilvestrol is a specialized natural product derivative belonging to the rocaglate class of compounds, known for its potent and selective biological activity. This high-purity compound is of significant interest for advanced research and development in life sciences, particularly in the study of novel therapeutic pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in oncology and virology research programs.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active investigational compound in the discovery of new anti-cancer and anti-viral agents.
• Mechanism of Action Studies: Used in biochemical and cellular assays to study the inhibition of eukaryotic translation initiation, specifically targeting the eIF4A RNA helicase.
• Preclinical Development: Employed in in vitro and in vivo studies to evaluate pharmacokinetics, pharmacodynamics, and efficacy profiles.
• Academic Research: A critical tool for universities and research institutes exploring cell signaling pathways, apoptosis, and novel targets for oncology.
• Biomarker Discovery: Used in proteomics and genomics research to identify downstream effects and potential biomarkers of drug response.
• High-Throughput Screening (HTS): Acts as a positive control or a lead compound in screening libraries for drug discovery campaigns.

Basic Information

Product Name	Episilvestrol
CAS No.	697235-39-5
Molecular Formula	C29H34O10
Molecular Weight	542.58 g/mol
Synonyms	(-)-Episilvestrol; 1H-Cyclopenta[b]benzofuran-5a,9b-diol, 4-[(1R,2R,3S,3aR,8bS)-6,8-dimethoxy-3a-(methoxymethyl)-1,2,3,3a,8b,9-hexahydro-1,2,3-trihydroxy-6H-cyclopenta[b][1]benzofuran-8-yl]-3a,4,7,7a-tetrahydro-7a-methyl-, (5aR,7aS,9bR)-; Rocaglate derivative; Flavagline compound
EINECS	Contact for details

Quality Control

Our Episilvestrol is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support research standards compliant with pharmacopeial guidelines where applicable, and custom synthesis and purification to meet specific project requirements are available.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.