Description

4-(4-Carbamoyl-Piperazine-1-Carbonyl)-Benzoic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its bifunctional benzoic acid and piperazine carboxamide structure. This compound is critical for medicinal chemists in the research and development of novel therapeutic agents, particularly as a key building block for constructing complex molecules with targeted biological activity. It is primarily utilized by R&D laboratories and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors seeking reliable, high-quality intermediates for API synthesis.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of Active Pharmaceutical Ingredients (APIs), particularly for candidates targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component connecting E3 ligase ligands to target protein binders.
• Kinase Inhibitor Synthesis: Incorporated into the molecular scaffold of potential kinase inhibitors due to the piperazine moiety's ability to modulate solubility and binding affinity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and non-commercial scale-up projects.
• Bioconjugation & Chemical Biology: The carboxylic acid group enables conjugation to other molecules, peptides, or surfaces for probe and tool compound development.

Basic Information

Product Name	4-(4-Carbamoyl-Piperazine-1-Carbonyl)-Benzoic Acid
CAS No.	693790-30-6
Molecular Formula	C13H15N3O4
Molecular Weight	277.28 g/mol
Synonyms	4-[(4-Carbamoylpiperazin-1-yl)carbonyl]benzoic acid; 4-(4-Carbamoylpiperazine-1-carbonyl)benzoic acid; Benzoic acid, 4-[(4-carbamoyl-1-piperazinyl)carbonyl]-; 1-[4-(Carboxy)benzoyl]-4-carbamoylpiperazine; 4-(Piperazine-1-carbonyl)benzamide-4-carboxylic acid; 4-Carboxy-N-(4-carbamoylpiperazin-1-yl)benzamide
EINECS	Contact for details

Quality Control

Our 4-(4-Carbamoyl-Piperazine-1-Carbonyl)-Benzoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.