Description

tert-Butyl 4-(2,2,2-trifluoroethyl)piperazine-1-carboxylate is a high-purity, protected piperazine derivative of significant interest in advanced organic synthesis. This compound serves as a critical pharmaceutical intermediate and building block for the development of novel active ingredients. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for constructing complex molecules with trifluoroethyl-substituted piperazine motifs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging the trifluoroethyl group for enhanced biological activity and metabolic stability.
• Chemical Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organocatalysts for asymmetric synthesis.
• Material Science Precursor: Potential intermediate in the synthesis of advanced polymers and functional materials with specific fluorinated properties.

Basic Information

Product Name	tert-Butyl 4-(2,2,2-Trifluoroethyl)Piperazine-1-Carboxylate
CAS No.	692058-21-2
Molecular Formula	C11H19F3N2O2
Molecular Weight	268.28 g/mol
Synonyms	1-Boc-4-(2,2,2-trifluoroethyl)piperazine; N-Boc-4-(2,2,2-trifluoroethyl)piperazine; tert-Butyl 4-(2,2,2-trifluoroethyl)-1-piperazinecarboxylate; 1-(tert-Butoxycarbonyl)-4-(2,2,2-trifluoroethyl)piperazine; 4-(2,2,2-Trifluoroethyl)piperazine-1-carboxylic acid tert-butyl ester; BOC-4-(2,2,2-Trifluoroethyl)piperazine; N-(tert-Butoxycarbonyl)-4-(2,2,2-trifluoroethyl)piperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2,2,2-trifluoroethyl)piperazine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.