Description

tert-Butyl 4-((6-Chloro-3-(3-(2-Chloro-3-Fluorophenyl)Ureido)-2-Hydroxyphenyl)Sulfonyl)Piperazine-1-Carboxylate is a sophisticated, high-purity chemical intermediate designed for advanced pharmaceutical synthesis and research. This compound is valued for its role as a key building block in the development of novel active pharmaceutical ingredients (APIs), particularly those targeting complex disease pathways. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex, small-molecule drug candidates, especially in oncology and central nervous system (CNS) research.
• API Process Development: Used in route scouting, optimization, and scale-up studies for new active pharmaceutical ingredients (APIs) requiring a piperazine-sulfonyl pharmacophore.
• Medicinal Chemistry Research: Enables the exploration of structure-activity relationships (SAR) by providing a versatile, functionalized scaffold for further chemical modification.
• Bioconjugation & Probe Synthesis: Can be utilized in the creation of chemical probes or labeled compounds for biochemical and pharmacological studies.
• Contract Manufacturing: Supplied to CDMOs for the cGMP production of clinical trial materials and commercial drug substances.

Basic Information

Product Name	tert-Butyl 4-((6-Chloro-3-(3-(2-Chloro-3-Fluorophenyl)Ureido)-2-Hydroxyphenyl)Sulfonyl)Piperazine-1-Carboxylate
CAS No.	688763-67-9
Molecular Formula	C22H25Cl2FN4O6S
Molecular Weight	563.42 g/mol
Synonyms	1-Boc-4-[(6-chloro-3-[[(2-chloro-3-fluorophenyl)carbamoyl]amino]-2-hydroxyphenyl)sulfonyl]piperazine; tert-Butyl 4-[(6-chloro-3-{[(2-chloro-3-fluorophenyl)carbamoyl]amino}-2-hydroxyphenyl)sulfonyl]piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-[(6-chloro-3-{[(2-chloro-3-fluorophenyl)carbamoyl]amino}-2-hydroxyphenyl)sulfonyl]piperazine; BOC-Piperazine Sulfonamide Derivative; CAS 688763-67-9
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical research and development work. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support development projects with custom purity grades and specifications tailored to your specific phase of research, from non-GMP to cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate for prolonged exposure. Keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.