Description

Ascrolimus (ABT-281) is a potent and selective small molecule inhibitor with significant research and development applications. This compound is of high interest for its targeted biological activity, making it a valuable tool for advancing scientific discovery. It is primarily utilized by pharmaceutical research organizations, biotechnology companies, and academic institutions engaged in drug discovery and biochemical pathway analysis.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in preclinical and clinical studies.
• Biochemical Pathway Analysis: Used as a selective probe to investigate specific cellular mechanisms and signal transduction pathways in vitro.
• Target Validation Studies: Employed to confirm the role and druggability of specific molecular targets in disease models.
• High-Throughput Screening (HTS): Acts as a control compound in assay development and screening campaigns to identify novel therapeutic agents.
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry and molecular biology.
• Contract Research Organizations (CROs): Supplied to CROs supporting drug discovery programs for external clients.

Basic Information

Product Name	Ascrolimus (ABT-281)
CAS No.	688308-92-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ABT-281; Ascrolimus; ABT 281; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-Dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
EINECS	Contact for details

Quality Control

Our Ascrolimus (ABT-281) is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research purposes. The product undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, well-ventilated area. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.