Description

4-(2-Amino-4-Methoxycarbonyl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core with protected amine and carboxylic acid functionalities. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and oncology therapeutics. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery, process development, and scale-up production.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those targeting neurological disorders and cancer.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) requiring a protected piperazine moiety.
• Medicinal Chemistry Research: Serves as a versatile scaffold in structure-activity relationship (SAR) studies and lead optimization in drug discovery pipelines.
• Process Chemistry: Employed in route scouting and the development of robust, scalable manufacturing processes for clinical and commercial drug supplies.
• Custom Synthesis: A starting material for the custom synthesis of more complex, proprietary compounds for pharmaceutical clients.

Basic Information

Product Name	4-(2-Amino-4-Methoxycarbonyl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	683274-46-6
Molecular Formula	C18H27N3O4
Molecular Weight	349.43 g/mol
Synonyms	tert-Butyl 4-(2-amino-4-(methoxycarbonyl)phenyl)piperazine-1-carboxylate; 4-(2-Amino-4-methoxycarbonylphenyl)piperazine-1-carboxylic acid tert-butyl ester; 1-Boc-4-(2-amino-4-(methoxycarbonyl)phenyl)piperazine; 683274-46-6; 4-(2-Amino-4-(methoxycarbonyl)phenyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1,1-Dimethylethyl 4-[2-amino-4-(methoxycarbonyl)phenyl]-1-piperazinecarboxylate
EINECS	Contact for details

Quality Control

Our 4-(2-Amino-4-Methoxycarbonyl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent quality suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.