Description

Piperazine, 1-(3,5-Difluoro-2-Pyridinyl)- (9Ci) is a specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique piperazine-pyridine scaffold is highly valued. Pharmaceutical research and development (R&D) teams, particularly those focused on central nervous system (CNS) and anti-infective drug candidates, are the primary industrial users of this high-purity chemical.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in neurological and psychiatric therapeutic areas.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, leveraging its fluorine-substituted aromatic system.
• Ligand Synthesis: Serves as a precursor for creating complex ligands used in catalysis and material science.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.
• Academic & Industrial R&D: Utilized in research laboratories for methodological development and exploring new chemical entities.

Basic Information

Product Name	Piperazine, 1-(3,5-Difluoro-2-Pyridinyl)- (9Ci)
CAS No.	683241-04-5
Molecular Formula	C9H11F2N3
Molecular Weight	199.20 g/mol
Synonyms	1-(3,5-Difluoropyridin-2-yl)piperazine; 2-(3,5-Difluoropyridin-2-yl)piperazine; 3,5-Difluoro-2-piperazin-1-ylpyridine; 2-(Piperazin-1-yl)-3,5-difluoropyridine; 1-(3,5-Difluoro-2-pyridinyl)piperazine; 683241-04-5 (CAS); 1-(3,5-Difluoro-pyridin-2-yl)-piperazine
EINECS	Contact for details

Quality Control

Our Piperazine, 1-(3,5-Difluoro-2-Pyridinyl)- (9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical documentation, including a Certificate of Analysis (COA) for each lot, detailing purity, identity, and impurity profiles as determined by HPLC, GC, NMR, and MS. Our quality commitment aligns with the standards expected for pharmaceutical intermediates, supporting our clients' regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.