Description

tert-Butyl 4-(3-Chloropyridin-2-Yl)Piperazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core protected by a Boc (tert-butoxycarbonyl) group and substituted with a chloropyridine moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of complex bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel drug candidates and active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drug candidates.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Synthesis: Serves as a building block for developing novel pesticides and herbicides due to its heterocyclic structure.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP conditions.

Basic Information

Product Name	tert-Butyl 4-(3-Chloropyridin-2-Yl)Piperazine-1-Carboxylate
CAS No.	683240-45-1
Molecular Formula	C14H20ClN3O2
Molecular Weight	297.78 g/mol
Synonyms	1-Boc-4-(3-chloropyridin-2-yl)piperazine; 1-(tert-Butoxycarbonyl)-4-(3-chloro-2-pyridinyl)piperazine; 4-(3-Chloro-2-pyridinyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-(3-chloro-2-pyridinyl)-1-piperazinecarboxylate; 2-(4-Boc-piperazin-1-yl)-3-chloropyridine; BOC-3-Chloro-2-Piperazinylpyridine; 683240-45-1
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(3-Chloropyridin-2-Yl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports applications in research and development under current Good Manufacturing Practice (cGMP) principles where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.