Description

Cyclopropanecarboxaldehyde, 2-Bromo-3-Methyl-, (1R,2S,3R)-Rel- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecular architectures with precise three-dimensional control, which is critical for developing bioactive molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Asymmetric Synthesis: Used in stereoselective reactions, such as nucleophilic additions and cycloadditions, to introduce the cyclopropane moiety with defined stereochemistry into target molecules.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) studies to explore the impact of the bromo-methyl-cyclopropyl group on potency, selectivity, and metabolic stability of lead compounds.
• Agrochemical Research: Acts as a building block for synthesizing novel pesticides and herbicides with potentially improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Can be utilized in the synthesis of chiral ligands and organocatalysts for enantioselective transformations.
• Academic Research: Used in universities and research institutes for methodological studies in organic chemistry and the synthesis of natural product analogs.

Basic Information

Product Name	Cyclopropanecarboxaldehyde, 2-Bromo-3-Methyl-, (1R,2S,3R)-Rel- (9Ci)
CAS No.	681537-05-3
Molecular Formula	C6H9BrO
Molecular Weight	177.04 g/mol
Synonyms	rel-(1R,2S,3R)-2-Bromo-3-methylcyclopropanecarbaldehyde; (1R,2S,3R)-2-Bromo-3-methylcyclopropanecarboxaldehyde; 2-Bromo-3-methylcyclopropanecarbaldehyde (rel); Bromomethylcyclopropanecarboxaldehyde; Cyclopropanecarboxaldehyde, 2-bromo-3-methyl-, (1R,2S,3R)-rel-; CAS 681537-05-3
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research and development. Each lot is characterized using advanced analytical techniques, including chiral HPLC, to confirm high enantiomeric and chemical purity. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. Allow the container to reach room temperature before opening to prevent moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.