Description

tert-Butyl 4-p-tolylpiperazine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the piperazine class of compounds. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) and other fine chemicals, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical producers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for the discovery of new therapeutic molecules.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a precursor in multi-step synthetic routes for the production of specific APIs.
• Fine Chemical Production: Employed in the manufacture of specialized, high-value chemicals for research and industrial applications.
• Contract Manufacturing: Supplied to CROs and CDMOs for custom synthesis projects and scale-up activities.
• Chemical Reference Standard: Can be used as a high-purity analytical standard for quality control and method development.

Basic Information

Product Name	tert-Butyl 4-p-tolylpiperazine-1-carboxylate
CAS No.	681482-19-9
Molecular Formula	C16H24N2O2
Molecular Weight	276.38 g/mol
Synonyms	1-Boc-4-(p-tolyl)piperazine; 4-(4-Methylphenyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-(4-methylphenyl)piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(p-tolyl)piperazine; 4-p-Tolylpiperazine-1-carboxylic acid tert-butyl ester; N-Boc-4-(4-methylphenyl)piperazine; Boc-4-(p-tolyl)piperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-p-tolylpiperazine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, and we can support custom purity or packaging requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.