Description

tert-Butyl 2-(Trifluoromethyl)-5,6-Dihydro-[1,2,4]Triazolo[1,5-A]Pyrazine-7(8H)-Carboxylate is a high-value, heterocyclic building block featuring a fused triazolopyrazine core with a trifluoromethyl group and a tert-butyloxycarbonyl (Boc) protecting group. This compound is critical for medicinal chemistry and pharmaceutical research, where it serves as a versatile intermediate for constructing complex molecules with enhanced metabolic stability and bioavailability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic programs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the trifluoromethyl group, which can improve lipophilicity and metabolic stability.
• Agrochemical Synthesis: Intermediate in the development of advanced herbicides, fungicides, or insecticides that require heterocyclic scaffolds.
• Chemical Biology Probes: Serves as a precursor for labeled compounds or probes used to study biological pathways and target engagement.
• Process Chemistry & Scale-Up: Employed in route scouting and pilot-scale synthesis for the commercial production of active pharmaceutical ingredients (APIs).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Product Name	tert-Butyl 2-(Trifluoromethyl)-5,6-Dihydro-[1,2,4]Triazolo[1,5-A]Pyrazine-7(8H)-Carboxylate
CAS No.	681249-59-2
Molecular Formula	C11H15F3N4O2
Molecular Weight	292.26 g/mol
Synonyms	7-Boc-2-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine; tert-Butyl 2-(trifluoromethyl)-5,8-dihydro-[1,2,4]triazolo[1,5-a]pyrazine-7(6H)-carboxylate; 2-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazine-7(8H)-carboxylic acid tert-butyl ester; 681249-59-2; Boc-protected trifluoromethyl triazolopyrazine; 7-(tert-Butoxycarbonyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyrazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(Trifluoromethyl)-5,6-Dihydro-[1,2,4]Triazolo[1,5-A]Pyrazine-7(8H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical data. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.