Description

2-(1-tert-Butoxycarbonylpiperazin-4-Yl)Propionic Acid is a high-purity, protected piperazine derivative used as a critical building block in advanced organic synthesis. This compound matters because it provides a versatile chiral scaffold for constructing complex molecules with precise stereochemistry. Pharmaceutical and biotechnology R&D teams need it for the development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially those containing a piperazine moiety.
• Peptidomimetic Research: Used to introduce constrained, non-natural amino acid analogs into peptide chains to enhance stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex organic molecules on scale.

Basic Information

Product Name	2-(1-tert-Butoxycarbonylpiperazin-4-Yl)Propionic Acid
CAS No.	680579-19-5
Molecular Formula	C₁₂H₂₂N₂O₄
Molecular Weight	258.31 g/mol
Synonyms	2-(1-Boc-piperazin-4-yl)propionic acid; 2-[4-(tert-Butoxycarbonyl)piperazin-1-yl]propanoic acid; (R/S)-2-(1-Boc-piperazin-4-yl)propionic acid; 1-Boc-4-(1-carboxyethyl)piperazine; 2-(4-N-Boc-piperazinyl)propionic acid; Boc-4-(1-carboxyethyl)piperazine; 680579-19-5; tert-Butyl 4-(1-carboxyethyl)piperazine-1-carboxylate
EINECS	Contact for details

Quality Control

Our 2-(1-tert-Butoxycarbonylpiperazin-4-Yl)Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.