Description

Spiro[1H-Indene-1,4′-Piperidine]-3-Acetic Acid, 2,3-Dihydro-, Hydrochloride (1:1) is a high-purity, advanced pharmaceutical intermediate with the CAS number 676607-36-6. This compound is valued for its complex spirocyclic and heterocyclic structure, which serves as a critical building block in modern medicinal chemistry. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic targets.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the multi-step synthesis of complex target molecules for preclinical and clinical studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development.
• Academic Research: Utilized in university and institutional labs for exploring new synthetic methodologies and biological activities.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Spiro[1H-Indene-1,4′-Piperidine]-3-Acetic Acid, 2,3-Dihydro-, Hydrochloride (1:1)
CAS No.	676607-36-6
Molecular Formula	C16H21NO2 • HCl
Molecular Weight	295.80 g/mol (free base: 259.34 g/mol)
Synonyms	2,3-Dihydrospiro[1H-indene-1,4'-piperidine]-3-acetic acid hydrochloride; Spiro[indane-1,4'-piperidine]-3-acetic acid hydrochloride; 676607-36-6; UNII-8W8T171F1U; 3-Acetic acid, 2,3-dihydrospiro[1H-indene-1,4'-piperidine]-, hydrochloride (1:1); 2,3-Dihydro-1'H-spiro[indene-1,4'-piperidine]-3-acetic acid hydrochloride
EINECS	Contact for details

Quality Control

Our Spiro[1H-Indene-1,4′-Piperidine]-3-Acetic Acid, 2,3-Dihydro-, Hydrochloride (1:1) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture absorption. Recommended long-term storage at controlled room temperature (15-25°C).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.