Description

(S)-5-Amino-Piperidin-2-One Hcl is a high-purity chiral piperidinone derivative, serving as a critical building block in modern pharmaceutical synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with specific stereochemistry, essential for developing targeted therapeutics. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly in areas like neurology and oncology.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel drug candidates, especially protease inhibitors and other enzyme-targeted therapies.
• API Development: Used in research and development for constructing the core scaffold of potential Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Employed as a starting material or intermediate in asymmetric synthesis routes to introduce the (S)-configured amino piperidinone moiety.
• Medicinal Chemistry Research: Serves as a valuable building block in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Bioconjugation & Probe Synthesis: Potential use in creating biochemical probes or for bioconjugation applications due to its reactive amino group.
• Custom Synthesis: A key starting point for custom synthesis services catering to specialized pharmaceutical and biotech research projects.

Basic Information

Product Name	(S)-5-Amino-Piperidin-2-One Hydrochloride
CAS No.	672883-95-3
Molecular Formula	C5H11N2O·HCl
Molecular Weight	150.62 (Free base) / 187.08 (HCl salt)
Synonyms	(S)-5-Aminopiperidin-2-one hydrochloride; (2S)-5-Amino-2-piperidinone hydrochloride; (S)-5-Amino-2-piperidinone HCl; (S)-2-Oxo-5-aminopiperidine hydrochloride; (S)-5-Azanylpiperidin-2-one hydrochloride; (S)-Amino-δ-valerolactam hydrochloride; (S)-5-Amino-2-piperidone HCl
EINECS	Contact for details

Quality Control

Our (S)-5-Amino-Piperidin-2-One Hcl is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral purity, and impurity profiles. While typically supplied as a high-purity research grade, production can be aligned with cGMP standards for advanced development stages upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.