Description

1-Boc-3-p-Tolylpiperazine is a high-purity, protected piperazine derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in providing a versatile and reactive nitrogen-containing scaffold for constructing complex pharmaceutical molecules and fine chemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to introduce the 3-p-tolylpiperazine moiety into target structures under controlled conditions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific piperazine-based architectures.
• Ligand and Catalyst Development: Serves as a starting material for creating novel ligands used in asymmetric catalysis and metal complexation.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and tool compounds for studying biological pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental building block for custom synthesis projects and scale-up production under cGMP or ISO standards.
• Academic & Industrial R&D: Utilized in discovery chemistry for library synthesis and structure-activity relationship (SAR) studies.

Basic Information

Product Name	1-Boc-3-p-Tolylpiperazine
CAS No.	669695-60-7
Molecular Formula	C16H24N2O2
Molecular Weight	276.38 g/mol
Synonyms	tert-Butyl 3-(4-methylphenyl)piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-(4-methylphenyl)piperazine; 3-p-Tolyl-1-Boc-piperazine; 1-Boc-3-(4-methylphenyl)piperazine; N-Boc-3-(p-tolyl)piperazine; 1-N-Boc-3-(4-methylphenyl)piperazine; Piperazine, 3-(4-methylphenyl)-, 1-(1,1-dimethylethyl) ester; Boc-3-p-Tolylpiperazine
EINECS	Contact for details

Quality Control

Our 1-Boc-3-p-Tolylpiperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.