Description

Thp-Peg9-Oh CAS NO 669556-83-6 is a specialized polyethylene glycol derivative featuring a tetrahydropyranyl (THP) protecting group. This bifunctional molecule is valued for its role as a versatile linker and spacer in advanced organic synthesis and bioconjugation. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors. The compound enables precise control over molecular architecture in the development of complex drug delivery systems and diagnostic agents.

Application

• Pharmaceutical Intermediates: Serves as a key building block and hydrophilic spacer in the synthesis of prodrugs, antibody-drug conjugates (ADCs), and targeted therapeutics.
• Bioconjugation Chemistry: Used to link active pharmaceutical ingredients (APIs) to targeting moieties like antibodies or peptides, improving solubility and pharmacokinetics.
• Polymer Chemistry: Acts as a functional initiator or monomer for creating tailored, water-soluble polymers with specific terminal functionalities.
• Cross-linking Agent: Employed in the preparation of hydrogels and biomaterials for controlled drug release and tissue engineering applications.
• Surface Modification: Utilized to PEGylate nanoparticles, liposomes, and other drug carrier systems to enhance stability and reduce immunogenicity.
• Research & Development: A critical reagent in academic and industrial R&D for exploring new synthetic pathways and bioconjugation strategies.

Basic Information

Product Name	Thp-Peg9-Oh
CAS No.	669556-83-6
Molecular Formula	C23H46O12
Molecular Weight	502.61 g/mol
Synonyms	2-(2-(2-(2-(2-(2-(2-(2-(2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethanol; THP-PEG9-OH; Tetrahydropyranyl-PEG9-alcohol; 2-[2-[2-[2-[2-[2-[2-[2-[2-(Oxan-2-yloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol; α-THP-ω-hydroxy-nonaethylene glycol; THP-protected PEG9 monoalcohol; PEG9 THP ether
EINECS	Contact for details

Quality Control

Our Thp-Peg9-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere (nitrogen or argon) is recommended to maintain optimal quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.