Description

4-Carboxymethyl-3-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for its versatility and reliability in multi-step synthetic pathways.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of complex drug molecules, including potential kinase inhibitors and other targeted therapies.
• Peptidomimetic Chemistry: Used to introduce functionalized piperazine scaffolds into peptide backbones to enhance stability, bioavailability, or receptor binding affinity.
• Agrochemical Synthesis: Serves as a precursor in the development of new-generation herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Employed in the synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Custom Chemical Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects and scale-up services.
• Academic and R&D: A valuable reagent for medicinal chemistry programs and methodological studies in academic and industrial research laboratories.

Basic Information

Product Name	4-Carboxymethyl-3-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	666853-16-3
Molecular Formula	C12H22N2O4
Molecular Weight	258.32 g/mol
Synonyms	tert-Butyl 4-(carboxymethyl)-3-methylpiperazine-1-carboxylate; 1-Boc-4-(carboxymethyl)-3-methylpiperazine; 3-Methyl-4-(carboxymethyl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(carboxymethyl)-3-methylpiperazine; 4-(Methoxycarbonylmethyl)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (common misnomer); 3-Methylpiperazine-1,4-dicarboxylic acid 1-tert-butyl ester; Boc-3-Me-4-CH2COOH-Pip
EINECS	Contact for details

Quality Control

Our 4-Carboxymethyl-3-Methyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.