Description

4-Methyl-Piperidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester is a high-purity, protected amino acid derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a sterically hindered, optically active piperidine scaffold that is essential for constructing complex molecular architectures with precise stereochemistry. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of piperidine-based drug candidates, including potential central nervous system (CNS) agents, receptor modulators, and enzyme inhibitors.
• Agrochemical Research: Used in constructing advanced intermediates for novel pesticides and herbicides that require specific stereochemistry for biological activity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for developing novel chiral ligands and organocatalysts used in enantioselective synthesis.
• Peptidomimetics & Bioactive Molecule Design: The protected dicarboxylic acid moiety makes it valuable for creating conformationally constrained peptide analogs and other bioactive compounds.
• Academic & Industrial R&D: A versatile building block in medicinal chemistry and process chemistry for exploring new chemical entities and optimizing synthetic routes.

Basic Information

Product Name	4-Methyl-Piperidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester
CAS No.	661459-03-6
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	1-tert-Butyl 2-methyl 4-methylpiperidine-1,2-dicarboxylate; 1-(tert-Butoxycarbonyl)-4-methylpiperidine-2-carboxylic acid methyl ester; 1-Boc-4-methylpiperidine-2-carboxylic acid methyl ester; 4-Methyl-1,2-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester; Methyl 1-Boc-4-methylpiperidine-2-carboxylate; tert-Butyl 4-methyl-2-(methoxycarbonyl)piperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our production of 4-Methyl-Piperidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high chemical purity. Quality is verified through modern analytical techniques including HPLC, GC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.