Description

2,5-Piperazinedione,3-[(2-Propenyloxy)Methyl]-,(3R)-(9Ci) is a high-purity, chiral piperazinedione derivative, a crucial advanced intermediate in modern pharmaceutical synthesis. Its value lies in its role as a sophisticated building block for constructing complex molecules with specific stereochemistry, enabling the development of targeted therapeutics. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and biotechnology sectors, particularly those focused on novel active pharmaceutical ingredients (APIs), peptide mimetics, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Peptidomimetic Scaffold: Serves as a constrained scaffold for designing and synthesizing peptide mimetics with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Utilized in asymmetric catalytic reactions and chiral pool synthesis due to its defined (3R) stereochemistry.
• Chemical Biology Research: Employed as a molecular probe or building block in medicinal chemistry for structure-activity relationship (SAR) studies and library development.
• Process Chemistry & Scale-Up: Used in the development and optimization of robust, scalable synthetic routes for advanced pharmaceutical intermediates under GMP-like conditions.

Basic Information

Product Name	2,5-Piperazinedione,3-[(2-Propenyloxy)Methyl]-,(3R)-(9Ci)
CAS No.	660862-77-1
Molecular Formula	C9H14N2O3
Molecular Weight	198.22 g/mol
Synonyms	(3R)-3-[(Allyloxy)methyl]piperazine-2,5-dione; (R)-3-(Allyloxymethyl)piperazine-2,5-dione; 3-[(2-Propen-1-yloxy)methyl]-2,5-piperazinedione, (3R)-; (3R)-3-(Allyloxymethyl)-2,5-diketopiperazine; DKP derivative, (R)-allyloxymethyl; Chiral 2,5-diketopiperazine intermediate; (R)-3-(Allyloxymethyl)-2,5-piperazinedione
EINECS	Contact for details

Quality Control

Every batch of our 2,5-Piperazinedione,3-[(2-Propenyloxy)Methyl]-,(3R)-(9Ci) is manufactured and tested under strict quality management systems to ensure identity, purity, and consistency. We provide comprehensive analytical data, including chiral purity verification, to support your regulatory and development needs. A detailed Certificate of Analysis (COA) with batch-specific results from HPLC, NMR, and optical rotation is available for each shipment, aligning with ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.