Description

(S)-Di-tert-Butyl 2-(2-Hydroxyethyl)Piperazine-1,4-Dicarboxylate is a high-purity, chiral piperazine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical industries for applications in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Peptidomimetic Chemistry: Used to introduce constrained piperazine scaffolds into peptide analogs to enhance metabolic stability and receptor binding affinity.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands used in asymmetric catalysis.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes and tool compounds for biological target validation.
• Custom Synthesis: A versatile starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke fine chemicals.

Basic Information

Product Name	(S)-Di-tert-Butyl 2-(2-Hydroxyethyl)Piperazine-1,4-Dicarboxylate
CAS No.	660862-48-6
Molecular Formula	C16H30N2O5
Molecular Weight	330.42 g/mol
Synonyms	(S)-1,4-Di-Boc-2-(2-hydroxyethyl)piperazine; (S)-2-(2-Hydroxyethyl)-1,4-piperazinedicarboxylic acid 1,4-di-tert-butyl ester; 1,4-Di-tert-butyl (S)-2-(2-hydroxyethyl)piperazine-1,4-dicarboxylate; (S)-1,4-Bis(tert-butoxycarbonyl)-2-(2-hydroxyethyl)piperazine; (S)-N,N'-Di-Boc-2-(2-hydroxyethyl)piperazine; (S)-2-(2-Hydroxyethyl)piperazine-1,4-dicarboxylic acid di-tert-butyl ester; (S)-DiBoc-hydroxyethylpiperazine; (S)-HOPip(Boc)2
EINECS	Contact for details

Quality Control

Our (S)-Di-tert-Butyl 2-(2-Hydroxyethyl)Piperazine-1,4-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.