Description

Thp-Peg10 is a specialized polyethylene glycol derivative featuring a tetrahydropyranyl (THP) protecting group. This compound is a crucial intermediate in organic synthesis and bioconjugation, offering a reactive handle for the controlled attachment of PEG chains to active molecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications requiring precise molecular engineering and solubility enhancement.

Application

• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of prodrugs and active pharmaceutical ingredients (APIs) requiring PEGylation for improved pharmacokinetics.
• Bioconjugation & Linker Chemistry: Used to attach polyethylene glycol (PEG) chains to peptides, proteins, or small molecules, leveraging the THP group as a protective moiety during synthesis.
• Polymer & Materials Science: Acts as a functional monomer or cross-linker in the development of smart hydrogels, drug delivery systems, and biocompatible coatings.
• Surface Modification: Employed to create PEGylated surfaces on nanoparticles, medical devices, or diagnostic tools to enhance biocompatibility and reduce non-specific binding.
• Solubility & Stability Enhancement: Incorporated into molecular structures to improve aqueous solubility and stability of hydrophobic compounds.
• Research & Development: A valuable tool in academic and industrial R&D for exploring novel drug delivery platforms and polymer architectures.

Basic Information

Product Name	Thp-Peg10
CAS No.	658858-65-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2-(Tetrahydro-2H-pyran-2-yloxy)poly(oxy-1,2-ethanediyl); THP-PEG10-OH; Tetrahydropyranyl-PEG10-alcohol; Poly(ethylene glycol) monomethyl ether THP ether (n~10); PEG10 THP ether; THP-protected PEG10; α-Tetrahydropyranyl-ω-hydroxy decaethylene glycol
EINECS	Contact for details

Quality Control

Our Thp-Peg10 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets precise specifications for research and production use. Certificates of Analysis (COA) documenting batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere or with appropriate desiccants to maintain product integrity. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Average Molecular Weight (GPC)	As per ordered grade

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.