Description

(2S,5R)-2,5-Dihydro-3,6-Dimethoxy-2-[(2S)-2-[[4-Methoxy-3-(3-Methoxypropoxy)Phenyl]Methyl]-3-Methylbutyl]-5-(1-Methylethyl)Pyrazine is a high-purity, chiral pyrazine derivative of significant interest in advanced pharmaceutical synthesis. This compound serves as a critical intermediate for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex stereochemistry. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in process chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and the production of kilogram-scale batches for clinical trial material (CTM) manufacturing.
• Asymmetric Synthesis: Employed in reactions requiring high enantiomeric purity due to its defined (2S,5R) stereochemistry.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and the generation of novel chemical libraries.
• Reference Standard: Provides a certified standard for analytical method development, validation, and quality control in API production.

Basic Information

Product Name	(2S,5R)-2,5-Dihydro-3,6-Dimethoxy-2-[(2S)-2-[[4-Methoxy-3-(3-Methoxypropoxy)Phenyl]Methyl]-3-Methylbutyl]-5-(1-Methylethyl)Pyrazine
CAS No.	656241-17-7
Molecular Formula	C28H44N2O6
Molecular Weight	504.66 g/mol
Synonyms	2,5-Dihydro-3,6-dimethoxy-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-(1-methylethyl)pyrazine, (2S,5R)-isomer; (2S,5R)-2,5-Dihydro-3,6-dimethoxy-2-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-5-isopropylpyrazine; Chiral Pyrazine Intermediate 656241-17-7; (2S,5R)-2-Isopropyl-5-[(2S)-2-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-3-methylbutyl]-3,6-dimethoxypyrazine
EINECS	Contact for details

Quality Control

Our (2S,5R)-2,5-Dihydro-3,6-Dimethoxy-2-[(2S)-2-[[4-Methoxy-3-(3-Methoxypropoxy)Phenyl]Methyl]-3-Methylbutyl]-5-(1-Methylethyl)Pyrazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.