Description

(αr,βs)-Rel-Bedaquiline CAS NO 654653-93-7 is a high-purity, stereochemically defined pharmaceutical intermediate and reference standard. This compound is of critical importance for research, development, and quality control within the pharmaceutical industry, specifically for antitubercular agents. It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in the synthesis and analysis of novel therapeutics for drug-resistant tuberculosis.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of Bedaquiline (TMC207) and its structural analogs.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) testing in API manufacturing.
• Research & Development: Essential for preclinical studies, metabolic pathway investigation, and impurity profiling.
• Regulatory Submissions: Serves as a characterized material for drug master files (DMFs) and regulatory documentation.
• Process Chemistry: Employed in route scouting and optimization for scalable GMP production.

Basic Information

Product Name	(αr,βs)-Rel-Bedaquiline
CAS No.	654653-93-7
Molecular Formula	C32H31BrN2O2
Molecular Weight	555.51 g/mol
Synonyms	(1R,2S)-rel-1-(6-Bromo-2-methoxy-3-quinolinyl)-4-(dimethylamino)-2-(1-naphthalenyl)-1-phenyl-2-butanol; (R,S)-Bedaquiline; Bedaquiline Related Compound; TMC207 Intermediate; (1R,2S)-Bedaquiline (relative configuration); SIRTURO Intermediate; (αr,βs)-Bedaquiline
EINECS	Contact for details

Quality Control

Our (αr,βs)-Rel-Bedaquiline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets exacting standards for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and related substances is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (αr,βs isomer)
Related Substances (HPLC)	Individual unknown impurity ≤0.5% Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.