Description

2-Chloro-3-(3-Methylpiperazin-1-Yl)Pyrazine is a high-purity heterocyclic organic compound featuring a pyrazine core substituted with chlorine and a methylpiperazine group. This specific molecular architecture makes it a critical building block (advanced intermediate) for the synthesis of complex active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily required by pharmaceutical R&D laboratories, contract research/manufacturing organizations (CROs/CMOs), and agrochemical innovators engaged in developing new therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of novel drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Serves as a versatile scaffold for developing new-generation herbicides, fungicides, and insecticides with targeted modes of action.
• Chemical Biology & Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and library synthesis for high-throughput screening and hit-to-lead optimization.
• Ligand & Catalyst Development: Employed in the design and synthesis of novel chelating ligands or organocatalysts for asymmetric synthesis.
• Material Science Research: Potential monomer or functionalizing agent for creating specialty polymers with tailored electronic or photophysical properties.

Basic Information

Product Name	2-Chloro-3-(3-Methylpiperazin-1-Yl)Pyrazine
CAS No.	651047-93-7
Molecular Formula	C9H12ClN5
Molecular Weight	225.68 g/mol
Synonyms	2-Chloro-3-(3-methyl-1-piperazinyl)pyrazine; 3-(3-Methylpiperazin-1-yl)-2-chloropyrazine; 2-Chloro-3-(3-methylpiperazin-1-yl)pyrazine; Pyrazine, 2-chloro-3-(3-methyl-1-piperazinyl)-; 651047-93-7; 2-Chloro-3-(3-methylpiperazino)pyrazine
EINECS	Contact for details

Quality Control

Our production of 2-Chloro-3-(3-Methylpiperazin-1-Yl)Pyrazine adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; therefore, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture uptake and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.